Start by pureeing the prickly pears. If your prickly pears are, indeed, prickly, I suggest wearing a sturdy pair of gloves to handle them. Cut the prickly pears in half lengthwise, and use a spoon or your fingers to remove the fruit from the outer skin. Discard the skins, and place the inner fruit into the bowl of your blender or food processor.
Blend until liquid, then pour through a fine mesh strainer to remove the seeds. You should have about a half cup of juice.
Add the prickly pear juice, honey, tequila, lime juice, orange juice, and orange liqueur to a cocktail shaker with ice, and shake hard for about thirty seconds, or until the shaker is super cold and frosty.
To rim the glasses, rub a wedge of lime around the edges and dip into flaked salt. Add ice to each glass, then pour in the margaritas. Serve.
Recipe by Will Cook For Friends at https://www.willcookforfriends.com/2014/09/prickly-pear-margaritas.html